Inflammation is part of the innate immune response to danger signals, tissue destruction, and/or infection. In this review, we will present the tumors associated with chronic inflammation, and PDE4B potential clinical application. Recent studies have identified phosphodiesterase 4B (PDE4B), a member of the phosphodiesterase (PDEs) protein family, as a major cyclic AMP (cAMP) metabolizing enzyme in inflammatory cells, and the therapeutic role of PDE4B as chronic inflammation, cancer. Therefore, the specific relationship and cellular mechanisms between inflammation and cancer are a hot topic of research. Moreover, chronic colorectitis is more likely to develop into colorectal cancer. The relationship between chronic inflammation and cancer development has been widely accepted, and chronic inflammation has been associated with the development of many cancers, including chronic bronchitis and lung cancer, cystitis inducing bladder cancer. macrophages, neutrophils, leukocytes, etc.). The presence of chronic inflammation is an important component of the tumor microenvironment produced by a variety of inflammatory cells (eg. chemical irritants, bacteria, viruses, etc.), and when the stimuli are persistent, they tend to trigger chronic inflammation. Inflammation is a response of the body to external stimuli (eg.
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